SANTA CLARA, CA and SOMERVILLE, MA, October 18, 2007—Symyx Technologies, Inc. (Nasdaq: SMMX) is pleased to announce out-of-the-box integration between the Symyx Isentris® informatics system (previously MDL Isentris) and the TIBCO® Spotfire DecisionSite visual analytics platform. Tight integration between the Isentris data integration system and TIBCO Spotfire’s world-class visualization software equips researchers to find the right data and leverage the best combination of research tools to make the right decisions in R&D.

The collaboration is the result of strategic partnership between Symyx and TIBCO Spotfire. "The partner program is designed to ensure that researchers' favorite applications work closely with Isentris to accelerate workflows," said Timothy Campbell, President of Symyx Software. “Integration of Symyx Isentris and Spotfire DecisionSite is an especially powerful combination for researchers. As a valued Symyx partner, TIBCO Spotfire brings indispensable visualization tools to researchers engaged in lead identification, lead optimization and structure-based drug design. At the same time, Symyx Isentris delivers information in new, improved ways to the TIBCO Spotfire platform.”

"TIBCO Spotfire and Symyx together are providing research organizations with a unique competitive advantage," stated Christopher Ahlberg, executive vice president, TIBCO Spotfire Division. "Out-of-the-box compatibility between the industry-leading systems for visual analytics and data integration enables researchers to interact with their data in a radically faster environment and quickly achieve useful insights."

In the face of increasing data volume and complexity, Symyx Isentris is a scientist-centric research environment that integrates commercial and in-house data with workflow applications, calculators, predictors and other tools to help researchers work smarter, collaborate more effectively and make better informed, timelier decisions.

TIBCO Spotfire offers a direct, interactive, visual approach to data analysis that enables researchers to quickly and easily spot trends, outliers and unanticipated relationships in large, complex datasets. Integration of the Symyx Isentris and TIBCO Spotfire systems provides researchers with powerful, advanced data visualization capabilities, enabling them to explore informative Structure Activity Relationships, carry out rich structure analyses, accelerate lead identification/optimization, analyze datasets more easily and make decisions faster.

Working within Isentris, researchers can locate and pull together disparate data from multiple internal and external sources. Researchers can then send the data to Spotfire DecisionSite (separate license required) to visualize, analyze and interpret structures, scaffolds/Rgroups, test results, property data, calculated properties, etc. and subsequently return the results to Symyx Isentris for further investigation, decision-making and reporting. Researchers can use guides and the publishing capabilities of Spotfire DecisionSite Posters to share pre-configured visualizations with colleagues—integrating informative visual analyses into the daily decision-making process within the Isentris workflow.

See how the Isentris informatics system integrates with TIBCO Spotfire DecisionSite to speed the visualization of data relationships:

• Visit www.mdl.com/videos and view the video entitled "Use your favorite tools." This brief video shows how Isentris works directly with specialized software like Spotfire DecisionSite to process, enrich and visualize data.
• Sign up for an informative Web Seminar entitled "Spotfire DecisionSite and MDL Isentris: interactive visualization of data" to be jointly hosted by Symyx and TIBCO Spotfire on October 23, 2007. This session for scientists will show a workflow in which data is sent to DecisionSite for visualization and filtering and then returned to Isentris for further investigation and reporting. Visit www.mdl.com/webinars for additional details and times.

Symyx Technologies, Inc. is the R&D execution partner to the life sciences, chemicals, energy, consumer products and electronics industries. Symyx provides electronic lab notebook and scientific decision-support software, automated lab systems (workflows) and collaborative research services to improve R&D productivity. In October 2007, Symyx acquired MDL Information Systems, Inc., a leading provider of innovative informatics software, databases and services that accelerate successful scientific R&D by improving the speed and quality of scientists' decision making. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com.

Spotfire, a division of TIBCO Software Inc., is a leading provider of enterprise analytics software for next generation business intelligence. Spotfire offers a visual and interactive experience that helps professionals quickly discover new and actionable insights in information. Distinguished by its speed to insight and adaptability to specific business challenges, Spotfire rapidly reveals unseen threats and new opportunities, creating significant economic value. Spotfire's customers include industry leaders among the Global 2000 that have deployed Spotfire analytics to gain an information advantage over their competitors. For more information, visit www.spotfire.tibco.com.