SANTA CLARA, CA, October 16, 2007—Symyx Technologies, Inc. (Nasdaq: SMMX) is pleased to announce that Syngene International Limited (a Biocon Company) has licensed Symyx's online DiscoveryGate content platform including CrossFire Beilstein, Patent Chemistry Database, Symyx Available Chemicals Directory (Symyx ACD) and a selection of Symyx Synthetic Methodology Databases. Syngene is a Bangalore-based custom research company offering multidisciplinary drug discovery services in synthetic chemistry and molecular biology.

"Accessing CrossFire Beilstein, Symyx ACD and a variety of complementary synthetic methodology databases through the DiscoveryGate interface is saving time, enhancing collaboration, accelerating decision-making and improving productivity at Syngene," said Dr. Madhavan Sridharan, Chief Scientific Manager at Syngene. "The ability to browse by reaction type in ChemInform Reaction Library is helping us immensely in the synthesis of novel compounds for custom projects."

"We are very pleased that Syngene has adopted DiscoveryGate," said Timothy Campbell, President of Symyx Software. "With our new dedicated presence in India now in place under the direction of Country Manager Dr. Sanjay Sanghani, we look forward to supporting research organizations in India with the best available integrated informatics and workflow resources."

The DiscoveryGate platform serves tens of thousands of researchers at more than 500 commercial, academic and government institutions worldwide and is supported on both the Microsoft® Windows® and Mac OS® X platforms.

DiscoveryGate provides detailed information on more than 27 million chemical compounds, 17 million reactions and 500 million observed chemical facts including synthesis, bioactivity, metabolism, toxicology, physical property, chemical sourcing, pharmacology and patent data. Researchers with the full DiscoveryGate platform can access 17 databases including the Beilstein and Gmelin databases, Symyx Available Chemicals Directory, MDDR, Symyx Toxicity Database and authoritative reference works on synthetic methodology such as ChemInform Reaction Library, Symyx Solid-Phase Organic Reactions, Symyx Reference Library of Synthetic Methodology, Derwent Journal of Synthetic Methods, ORGSYN and Integrated Major Reference Works. Researchers can also search compounds in PubChem and the Derwent World Patents Index® and link to over 20,000 journal titles (additional licenses required to access certain third-party content).

To learn more about how Symyx's DiscoveryGate helps researchers find the information they need, visit www.discoverygate.com and sign up for a 30-day trial (no fee, no obligation to buy, subject to acceptance of the applicable DiscoveryGate evaluation license) or request information at www.mdl.com. Inquiries regarding Symyx products and services in India may be directed to Dr. Sanjay Sanghani at s.sanghani@mdl.com, Tel: (+91) 98 737 655 02.

Symyx Technologies, Inc. is the R&D execution partner to the life sciences, chemicals, energy, consumer products and electronics industries. Symyx provides electronic lab notebook and scientific decision-support software, automated lab systems (workflows) and collaborative research services to improve R&D productivity. In October 2007, Symyx acquired MDL Information Systems, Inc., a leading provider of innovative informatics software, databases and services that accelerate successful scientific R&D by improving the speed and quality of scientists' decision making. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com.