Santa Clara, California, January 13, 2009 – Symyx Technologies, Inc. (Nasdaq: SMMX) announced that Schering-Plough Corporation has licensed Symyx Notebook in support of the company's initiative to equip Schering-Plough research scientists across the company's global R&D operations with a single, enterprise-wide electronic lab notebook.

“By providing a common, shared notebook across the enterprise, Symyx Notebook can help researchers achieve better compliance, improved collaboration, and support for integration and harmonization of procedures across sites,.” said Isy Goldwasser, Symyx chief executive officer. “We look forward to supporting Schering Plough's efforts to speed the discovery and development of innovative pharmaceutical products that deliver better outcomes for patients.”

Schering-Plough will also collaborate with Symyx to develop within the Symyx Notebook a commercial metrology module built on the Symyx Lab Operational Informatics platform. The metrology module can enable researchers to track and manage equipment usage and calibration directly within their Notebook workflows.

Symyx Notebook is an enterprise electronic lab notebook that helps scientists quickly and easily record, find, report, and reuse experiments-while effectively sharing information with colleagues and contract research organizations over global networks. Symyx Notebook is uniquely designed to be used out-of-the-box across many scientific disciplines including analytical chemistry, synthesis chemistry, and biology; from discovery through manufacturing. The notebook consolidates experimental data, forms data, and text into fully versioned, searchable documents controlled by customizable document workflows, electronic signatures, and security protocols that are appropriate for use in both regulated and non-regulated research organizations.
For more information about Symyx Notebook, visit www.symyx.com/notebook6  or contact inforequest@symyx.com.

Symyx Technologies, Inc. (NASDAQ: SMMX) enables companies in life sciences, chemicals and energy, and consumer and industrial products to transform scientific R&D and achieve extraordinary breakthroughs in productivity and return on investment. Symyx scientific information management enables scientists to design, execute, analyze, and report experimental results faster, easier, and less expensively. Symyx microscale, parallel experimentation enables a single scientist to rapidly explore a broad experimental space and develop comprehensive data sets in days – not weeks or months. Symyx contract research delivers these advantages on a customer-directed project basis and enables companies to increase R&D productivity, agility, and flexibility. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com.