SUNNYVALE, Calif., January 21, 2010 - Symyx Technologies, Inc. (Nasdaq: SMMX) today announced that Isy Goldwasser, the Company's Chief Executive Officer, is scheduled to present at the Jefferies 2010 Global Healthcare Services Conference in New York on January 25 at 2:15 p.m. Eastern Time.

A live webcast of the presentation may be accessed over the internet at http://investor.symyx.com/events.cfm. The webcast audio and slides will be available for a period of thirty days.

Symyx Technologies, Inc. (NASDAQ: SMMX) enables companies in life sciences, chemicals and energy, and consumer and industrial products to transform scientific R&D and achieve extraordinary breakthroughs in productivity and return on investment. Symyx scientific information management enables scientists to design, execute, analyze, and report experimental results faster, more easily, and less expensively. Symyx microscale, parallel experimentation enables a single scientist to rapidly explore a broad experimental space and develop comprehensive data sets in days – not weeks or months. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com.

Symyx is a registered trademark of Symyx Technologies, Inc. All rights reserved.