Access people, technology and application know-how to facilitate data creation
Need fast comprehensive data sets but project demand does not justify in-house investment?
Symyx Research offers new experiment execution services to create comprehensive data sets to explore large and complex experimental spaces in solubility, solid form selection, stability and process development. Symyx Research creates data sets around properties of interest that your scientists can model and mine to achieve better product attributes, speed time to market and access when needed. Your scientists are drug development experts and can design and analyze experiments they need, our labs provide experiment execution to give your scientists the information they need to make decisions with certainty.
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Focus on science and drug development not experiment execution
Use Symyx Research to provide experiment capability on demand. Symyx uses automation and informatics technology to generate comprehensive datasets in days not months. Research programs are flexible and allow you to engage from a single experiment screen to hundreds of screens per year. Use technology to achieve a dramatic decrease in cost per experiment and free your scientist’s time to focus on science.
Preformulation and formulation
Characterize API and drug product for key parameters required for drug development around solubility, solid form selection and stability.
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Solubility |
Determine API solubility versus a broad range of biosimulated fluids, viscous media (Tween’s, PEGs, dilute acids), solvent systems, impurities, temperature and/or pH |
Obtain solubility in mg/ml, purity measured by LC, pH and sample images |
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Polymorph Screening |
Identify new crystalline and co-crystalline forms of drug substances and the conditions required to generate them exploring a wide range of solvent systems, temperatures and crystallization methods |
Obtain clustered polymorph data sets including XRD and Raman, identify degradation and purity via HPLC. |
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Salt Selection |
Explore reaction conditions for optimal salt synthesis including pH, API concentration, acid or base stoichiometry, solvent, time and temperature |
Obtain key salt forms identified by XRD and Raman and the conditions used to create them. Scale-up experiments and analyze by DSC, TGA and NMR. |
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Stability |
Identify the conditions that cause API and/or liquid formulations to degrade over time. Investigate the effects of acids, bases, oxidizers, radical generators, pH and co-solvents under forced conditions (temperature, humidity and luminescence) |
Obtain intrinsic stability, degradation kinetics and impurity profiles. |
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Excipient Compatibility |
Determine potentially incompatible excipients and drug products as a function of time, environment and drug loading |
Obtain rates of degradation and impurity profiles |
Process Development
Quickly identify key process conditions, parameters and catalyst levels for route selection and early process development for asymmetric hydrogenation, cross-coupling, enantioselective transformations, enzymatic catalysis and non-catalyzed transformations.
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Process Screening |
Map a broad synthetic space to identify promising conditions including; catalyst, additives, ligand and solvent selection |
Obtain key parameters for optimization, assay yields for different routes and isolated yields from scale-up experiments. . |
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Process Optimization |
Determine process conditions and parameters (such as catalyst loading, temperature, pressure, concentrations, etc) to give a highly optimized process resulting in high yield, high selectivity and reduced raw material costs |
Obtain process parameters that results in the most optimized process for synthetic steps. |